Experimental Studies on Salt Hypertension (Rat) I : DCA HYPERTENSION AND ACUTE SALT HYPERTENSION

Salt handling and hypertension.

The kidney plays a central role in our ability to maintain an appropriate sodium balance, which is critical for the determination of blood pressure. The kidney's capacity for salt conservation may not be widely appreciated, and in general we consume vastly more salt than we need. Here we consider the socioeconomics of salt consumption, outline current knowledge of renal salt handling at the mol...

Molecular Mechanisms of Experimental Salt-Sensitive Hypertension

H ypertension has been defined operationally as the level of blood pressure (BP) at which the benefits of treatment exceed the risks.1 It also has been defined in a more concrete way by the Joint National Committee on Hypertension (JNC7) as, in adults, a systolic BP ≥140 mm Hg or a diastolic BP ≥90 mm Hg.2 Hypertension has been shown to be a risk factor for a variety of morbidities, especially ...

Dietary Salt Intake and Hypertension

Over the past century, salt has been the subject of intense scientific research related to blood pressure elevation and cardiovascular mortalities. Moderate reduction of dietary salt intake is generally an effective measure to reduce blood pressure. However, recently some in the academic society and lay media dispute the benefits of salt restriction, pointing to inconsistent outcomes noted in s...

Salt Sensitive Hypertension and Orexin

Salt, Hypertension, and Cardiovascular Diseases

The relationship between salt and hypertension is well established, and salt restriction is widely recommended in the management of hypertension. However, people living in northeast Asia have consumed large amount of salt, and the prevalence of hypertension and the incidence of stroke have been high in that area. Mechanisms of salt-induced hypertension may be complex, but volume expansion in th...